Erectile dysfunction is also known as impotence which is a condition where a person is not able to maintain an erection during a sexual intercourse. Now there are many factors that are responsible for causing this disorder in a person. Suffering from erectile dysfunction can not only affect the person physically but can also produce mental pressure on the person. During this condition, the blood vessel of the lower abdomen narrows down thus causing improper blood flow into the organ. Kamagra, however, relaxes the smooth muscle that is present in the wall of the blood vessel which helps in increasing the flow of blood in the lower abdomen of the body. This is very effective in treating conditions like erectile dysfunction. To get the medicine at a reasonable and affordable price you can buy Kamagra online from buy generic medicin.
Kamagra 100 mg tablets contain sildenafil as the key or the active ingredient of the medicine. It also contains a number of inactive ingredients such as the magnesium stearate, microcrystalline cellulose, calcium hydrogen phosphate (anhydrous), croscarmellose sodium, hypromellose, titanium dioxide (E171), lactose, triacetin, indigo carmine aluminum lake (E132).
The key ingredient used in the medicine is sildenafil. During the year 1990, many pharmaceutical companies achieved success in developing a compound that stimulates the phosphodiesterases type-5 enzyme that is responsible for maintaining the erection on the men. It was first synthesized by Pfizer. The compound used was first studied for hypertension and angina pectoris. The clinical trials were first conducted in the Morriston Hospital in Swansea. He found out that it had little effect on angina pectoris. But it did make a major improvement in people suffering from erectile dysfunction. Therefore Pfizer decided to market the medicine for erectile dysfunction.
As in people suffering from erectile dysfunction, the blood vessel of the person narrows down thus causing slow blood flow into the region. Kamagra works by relaxing the smooth muscle of the walls of the blood vessel and allowing the free flow of the blood into the organ. The medicine starts working within thirty minutes of intake. However, it is important to note that this is not an aphrodisiac and therefore will not be able to give you an erection if there is no sexual stimulation. The sildenafil that is the key ingredient of the medicine is very potent in protecting the cyclic guanosine monophosphate (cGMP) from getting degraded by the cGMP-specific phosphodiesterases type 5 (PDE5) in the corpus cavernosum.
The nitric oxide present in the corpus cavernosum then binds to the guanylate cyclase receptor that helps in increasing the level of cGMP thus relaxing the smooth muscle of the intimal cushion of the organ. Thus the relaxation of the smooth muscle leads to the vasodilation and also increases the inflow of blood into the organ’s spongy tissue thus causing an erection. In the year 1998, Robert F. Furchgott, Ferid Murad and Louis Ignarro won the Nobel prize in medicine for the study of the metabolic pathway of nitric oxide in the smooth muscle vasodilatation. The sildenafil is a potent and selective inhibitor of the cGMP type 5 (PDE5) thus responsible for the degradation of the cGMP in the corpus cavernosum.
Since the molecular structure of the sildenafil is very much similar to that of the cGMP, therefore, it acts as a competitive binding agent of the PDE5 thus resulting in more cGMP and a better erection. However, without the presence of the sexual stimulation and in the lack of nitric oxide in the system the sildenafil does not cause an erection. The active ingredient of the medicine is then broken down in the liver by the hepatic metabolism. The metabolite is therefore responsible for about 20 % of the sildenafil’s action. The sildenafil is execrated predominantly in the feces and in a very lesser amount in the urine.
This medicine is used to mainly treat erectile dysfunction. Use of Kamagra 100mg can treat impotence that helps in achieving and sustaining the erection. However, the medicine only works in the presence of sexual stimulation. Using of Kamagra for treating pulmonary arterial hypertension is of great advantage. Many medical professionals suggest the use of Kamagra 100mg to treat high blood pressure of the arteries that are present in the lungs and the right side of the heart. It is also helpful in improving the exercise capacity of the person taking the drug.
Almost all drugs interact differently in different person. These medicines when interact can alter the action of the drug in the body.
Interaction with Alcohol- it is seen that the use of alcohol while taking Kamagra tablet may increase the blood pressure of the person and thus lowering the effect of this medicine. Therefore it is very important to avoid using alcohol with the medicine. People taking Kamagra with alcohol suffer from symptoms like dizziness, fainting, flushing, and persistent headaches.
Interaction with medicines-
It is very important to avoid using grapefruit juice in large quantities while taking Kamagra tablet. Consuming grapefruit juice while having Kamagra will lead to interfering with the working of the medicine in the body.
While taking the medicine it is important to keep the following points in mind. Doing so the benefits of the medicine will reach the optimal level.
Remembering the following points while taking Kamagra is important-
Almost all medicine has some kind of side effect associated with them, just that some are severe and others are mild. As all of us have a different immune response to a particular compound therefore not everyone gets a side effect after taking the medicine. Some of the commonly seen side effects of Kamagra is-
It is very important to rush to a doctor when you notice any of the side effects on taking the medicine.
For sustaining the shelf life of the tablet it is very important to keep and store the medicine in the right and suitable place. Therefore keep in mind the points given below while storing the medicine-
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